does l carnitine cause insomnia

Acute and chronic effects of propionyl-L-carnitine on the hemodynamics, exercise capacity, and hormones in patients with congestive heart failure. View abstract. L-carnitine decreases severity and type of fatigue induced by interferon-alpha in the treatment of patients with hepatitis C. Neuropsychobiology 2003;47:94-7. 1-1-2010;84(1):52-58. View abstract. Grandis, D. D. Tolerability and efficacy of L-acetylcarnitine in patients with peripheral neuropathies: a short-term, open multicentre study. Gramignano, G., Lusso, M. R., Madeddu, C., Massa, E., Serpe, R., Deiana, L., Lamonica, G., Dessi, M., Spiga, C., Astara, G., Maccio, A., and Mantovani, G. Efficacy of l-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer therapy. Am J Kidney Dis. Neurobiol Aging 1995;16:1-4. View abstract. It helps transport fatty acids into the mitochondria where they can be burned up and used as fuel. [A systematic review of the effectiveness of alternative weight-loss products' ingredients]. Symptoms include relentless fatigue during the day, not feeling rested after sleep, insomnia, reduced sex drive, a "wired and tired" feeling, a reduced ability to concentrate and feel relaxed, and weight gain, especially in the stomach. J Intern Med 1993;233:94. 1991;13(1-2):135-146. Fan, J. P., Kim, H. S., and Han, G. D. Induction of apoptosis by L-carnitine through regulation of two main pathways in Hepa1c1c 7 cells. View abstract. Heinonen OJ. Pediatr.Hematol.Oncol. View abstract. 2008;28(8):495-500. Ann.Nutr.Metab 2008;52(4):335-338. Malaguarnera, M., Vacante, M., Avitabile, T., Malaguarnera, M., Cammalleri, L., and Motta, M. L-Carnitine supplementation reduces oxidized LDL cholesterol in patients with diabetes. Brunel-Guitton, C., Costa, T., Mitchell, G. A., and Lambert, M. Treatment of cobalamin C (cblC) deficiency during pregnancy. Malvagia, S., Papi, L., Morrone, A., Donati, M. A., Ciani, F., Pasquini, E., la, Marca G., Scholte, H. R., Genuardi, M., and Zammarchi, E. Fatal malonyl CoA decarboxylase deficiency due to maternal uniparental isodisomy of the telomeric end of chromosome 16. Medicine (Baltimore). Follow your doctor's instructions about any restrictions on food, beverages, or activity. Rogerson, M. E., Rylance, P. B., Wilson, R., De Sousa, C., Lanigan, C., Rose, P. E., Howard, J., and Parsons, V. Carnitine and weakness in haemodialysis patients. Ann N Y Acad Sci 2004;1033:42-51. Hemodial.Int. Am.J Kidney Dis 2008;52(5):962-971. De Pasquale, B., Righetti, G., and Menotti, A. Torrioli, M. G., Vernacotola, S., Peruzzi, L., Tabolacci, E., Mila, M., Militerni, R., Musumeci, S., Ramos, F. J., Frontera, M., Sorge, G., Marzullo, E., Romeo, G., Vallee, L., Veneselli, E., Cocchi, E., Garbarino, E., Moscato, U., Chiurazzi, P., D'Iddio, S., Calvani, M., and Neri, G. A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys. A., and Barrington, K. J. View abstract. View abstract. View abstract. 1987;24(4):231-234. View abstract. View abstract. Sports Med 1996;22:109-32. 2002;4(1):61-66. Select a condition to view a list of vitamins. Medically reviewed by Drugs.com on Jun 6, 2022. Minerva Urol.Nefrol. Malaguarnera, M., Vacante, M., Giordano, M., Motta, M., Bertino, G., Pennisi, M., Neri, S., Malaguarnera, M., Li, Volti G., and Galvano, F. L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-alpha 2b plus ribavirin. Spiering, B. For this reason, L-carnitine levels are often lower in vegetarians and vegans, since they restrict or avoid animal products (6, 62). 3. View abstract. Taking your CoQ10 with food not only helps . Vasc.Med 2012;17(3):145-154. View abstract. Biol Neonate 1990;58:81-8. View abstract. [Effect of L-carnitine on post-stress metabolism in surgical patients]. Propionyl-L-carnitine is likely to be safe when used under medical supervision. Shang R, Sun Z, Li H. Effective dosing of L-carnitine in the secondary prevention of cardiovascular disease: a systematic review and meta-analysis. View abstract. Persico G, Amato B, Aprea G, et al. Nasca D, Zurria G, and Aguglia E. Action of acetyl-L-carnitine in association with mianserine on depressed old people. Ramos AC, Elias PR, Barrucand L, Da Silva JA. View abstract. Ma, S. J., Cai, W. W., and Sheng, J. Drugs Exptl Clin Res 1992;18(1):29-36. Blood 1998;91:3817-24. J.Med.Sci.J.Islamic Azad Univ. Arch Neurol 1992;49:1137-41. The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. 2019 Apr;27(4):1491-1496. Ghidini O, Azzurro M, Vita G, Sartori G. Evaluation of the therapeutic efficacy of L-carnitine in congestive heart failure. Clin Physiol 1995;15(5):417-423. 2020;52(2):e13470. The effects of L-carnitine supplementation on performance during interval swimming. Monaldi Arch.Chest Dis 2007;68(2):110-114. 2004;34(6):615-623. View abstract. Effect of propionyl-L-carnitine, L-arginine and nicotinic acid on the efficacy of vardenafil in the treatment of erectile dysfunction in diabetes. A double-blinded, crossover study. In a 90-day study, people with alcohol addictions who took 2 grams of acetyl-L-carnitine per day experienced significant improvements in all measures of brain function (38). Bohles H, Sewell AC, Wenzel D. The effect of carnitine supplementation in valproate-induced hyperammonaemia. Very common (10% or more): Diarrhea (35%), abdominal pain (21%), vomiting (21%), nausea (12%), Common (1% to 10%): Constipation, dyspepsia, gastrointestinal disorder, melena, Very rare (less than 0.01%): Abdominal cramps[Ref], Very common (10% or more): Headache (37%), dizziness (18%), paresthesia (12%), Common (1% to 10%): Hypertonia, vertigo, taste perversion, Frequency not reported: Seizures (with or without pre-existing seizure activity), increase in seizure frequency and/or severity[Ref], There are reports from clinical trials of significant hypertriglyceridemia associated with high doses of levocarnitine (the active ingredient contained in L-Carnitine) (3 g/day) given to uremic dialysis patients. 1) is a naturally occurring amino acid found in high concentrations in muscle, heart and brain tissues. A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. Rausch CR, Paul S, Marx KR, et al. View abstract. Am J Clin.Nutr 2009;89(1):71-76. Yet, there are a few known side effects that include agitation, insomnia and nausea. Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: a double-blind, cross-over study. J Pharmacol Exp Ther 1999;290:1482-92. In fact, in one study, a small group of people with hyperthyroidism saw these symptoms improve, and their body temperature become normal, when taking carnitine. Fertil.Steril. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Milazzo, L., Menzaghi, B., Caramma, I., Nasi, M., Sangaletti, O., Cesari, M., Zanone, Poma B., Cossarizza, A., Antinori, S., and Galli, M. Effect of antioxidants on mitochondrial function in HIV-1-related lipoatrophy: a pilot study. Dev Med Child Neurol 1991;33:795-802. View abstract. Jimenez Caballero, P. E. and Marsal, Alonso C. [Type 1 glutaric aciduria: clinical and therapeutic implications]. Immunopharmacol.Immunotoxicol. Clin Trial J 1984;21:40-58. Schmidt-Sommerfeld E, Penn D. Carnitine and total parenteral nutrition of the neonate. World J Gastroenterol. Sulkers, E. J., Lafeber, H. N., Degenhart, H. J., Przyrembel, H., Schlotzer, E., and Sauer, P. J. Salonia, A. Med.Sci Monit. But doses of less than 3 grams a day seem safe for pretty much anyone. View abstract. Wolfe, L. A., He, M., Vockley, J., Payne, N., Rhead, W., Hoppel, C., Spector, E., Gernert, K., and Gibson, K. M. Novel ETF dehydrogenase mutations in a patient with mild glutaric aciduria type II and complex II-III deficiency in liver and muscle. Sugino, T., Aoyagi, S., Shirai, T., Kajimoto, Y., and Kajimoto, O. Z., Wang, L. X., Liu, H. Z., Qi, X. W., Wang, X. H., and Ren, H. Z. L-carnitine as an adjunct therapy to percutaneous coronary intervention for non-ST elevation myocardial infarction. Levocarnitine-induced hypophosphatemia in a hemodialysis patient with acute valproic acid toxicity. 2009;37(4):622-631. van Dalen, E. C., Caron, H. N., Dickinson, H. O., and Kremer, L. C. Cardioprotective interventions for cancer patients receiving anthracyclines. Z. Cardiovasc.Drugs Ther 2007;21(6):445-448. Effects of L-carnitine supplementation on the quality of life in diabetic patients with muscle cramps. First, take your CoQ10 with a meal. Effect of dialysate composition on the lipid response to L-carnitine supplementation. Clin Physiol 1984;4(4):363-365. Pediatr Res 1984;18:815-9. View abstract. Your L-carnitine levels are influenced by how much youre eating and how much your body is producing. Drugs Exp Clin Res 1995;21:187-98. Lancet 1989;2:469-73. Nephrologie 1998;19:171. View abstract. View abstract. View abstract. Perrott, J., Murphy, N. G., and Zed, P. J. L-carnitine for acute valproic acid overdose: a systematic review of published cases. Br.J Clin Pharmacol 2007;64(3):335-345. Metabolism 2009;58(11):1618-1623. It is used for weight loss and may have an impact on brain function. Malaguarnera, M., Bella, R., Vacante, M., Giordano, M., Malaguarnera, G., Gargante, M. P., Motta, M., Mistretta, A., Rampello, L., and Pennisi, G. Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy. Bull.Exp.Biol.Med. 2010;106(4):296-301. "L-carnitine and platelet aggregation in uremic patients subjected to hemodialysis." View abstract. 2005;59(4):592-596. Bodea, F., Bocea, A., and Decea, N. [L-carnitine decreases oxidative stress induced by experimental hypobaric hypoxia]. View abstract. Eidi, M., Pouyan, O., Shahmohammadi, P., Saeidi, H., Bahar, M., and Eidi, A. 2007;20(1):63-65. Mantovani G, Maccio A, Madeddu C, et al. However, there were some mild side effects, including nausea and stomach discomfort (24, 58). Drugs Aging 2006;23(3):263-270. Erbas, H., Aydogdu, N., Usta, U., and Erten, O. Eur J Clin Pharmacol 1998;54:503-8. 2009;48(5):587-596. As a supplement, acetyl-L-carnitine is usually considered safe when taken as directed. J Med.Toxicol. View abstract. Lebrun C, Alchaar H, Candito M, et al. Med.Sci Monit. View abstract. View abstract. View abstract. Tumori 2005;91(2):135-138. Ishikura H, Matsuo N, Matsubara M, et al. Nutr Metab Cardiovasc Dis 2019;29(11):1151-67. doi: 10.1016/j.numecd.2019.07.012. Neurology 1991;41:1726-32. Nikolaos, S., George, A., Telemachos, T., Maria, S., Yannis, M., and Konstantinos, M. Effect of L-carnitine supplementation on red blood cells deformability in hemodialysis patients. L-carnitine improves glucose disposal in type 2 diabetic patients. View abstract. View abstract. 12-3-1999;87(4):366-368. View abstract. A., Kraemer, W. J., Hatfield, D. L., Vingren, J. L., Fragala, M. S., Ho, J. Y., Thomas, G. A., Hakkinen, K., and Volek, J. S. Effects of L-carnitine L-tartrate supplementation on muscle oxygenation responses to resistance exercise. View abstract. View abstract. Mayo Clin Proc. Lim, C. Y., Jun, D. W., Jang, S. S., Cho, W. K., Chae, J. D., and Jun, J. H. Effects of carnitine on peripheral blood mitochondrial DNA copy number and liver function in non-alcoholic fatty liver disease. Acta Toxicol Ther 1990;11(2):173-184. Ann N Y Acad Sci 2004;1033:30-41. View abstract. Improved excercise tolerance after administration of carnitine. 2007;18(8):533-540. View abstract. View abstract. View abstract. Martinez E, Domingo P, Roca-Cusachs A. Potentiation of acenocoumarol action by L-carnitine. The main dietary sources of L-carnitine are meat, fish and some other animal products, such as milk. 2009;32(1):E13-E19. View abstract. View abstract. Speak with a healthcare provider to find out what dose might be best for a specific condition. Trovato GM, Ginardi V, Di Marco V, and et al. Ageing Res.Rev. Int.J Cardiol. Madsen KL, Preisler N, Orngreen MC, Andersen SP, Olesen JH, Lund AM, Vissing J. Acta Neurol.Scand. Ferrari R, Cucchini F, Dilisa F, and et al. Martinotti, G., Andreoli, S., Reina, D., Di, Nicola M., Ortolani, I., Tedeschi, D., Fanella, F., Pozzi, G., Iannoni, E., D'Iddio, S., and Prof, L. J. Acetyl-l-Carnitine in the treatment of anhedonia, melancholic and negative symptoms in alcohol dependent subjects. It can also cause a "fishy" odor of the urine, breath, and sweat. Rev.Med.Chil. View abstract. View abstract. 2011;37(10):1716-1717. 2006;16(4):281-287. Available for Android and iOS devices. View abstract. Acetyl-L-Carnitine is a potent brain enhancer that can help enhance your learning ability while protecting your brain. These 11 healthy foods can help you burn fat. Carnitine is also synthesized endogenously in the liver . Derosa, G., Cicero, A. F., Gaddi, A., Mugellini, A., Ciccarelli, L., and Fogari, R. The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus. A., and Morrow, G. R. Pharmacologic treatment of cancer-related fatigue. 2011;17(1):BR1-BR9. Circ Rep 2019;1(11):508-516. Perna, A. F., Acanfora, F., Satta, E., Lombardi, C., Capasso, R., Ingrosso, D., and De Santo, N. G. L-Propionyl carnitine, homocysteine and S-adenosylhomocysteine in hemodialysis. Effects of L-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the L-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) Trial. According to this work, published online in the journal Nature Medicine, eating red meat delivers L-carnitine to bacteria that live in the human gut. Kumar, R., Gautam, G., and Gupta, N. P. Drug therapy for idiopathic male infertility: rationale versus evidence. View abstract. It plays a crucial role in the production of energy by transporting fatty acids into your cells mitochondria (1, 2, 3). Malaguarnera, M., Vacante, M., Giordano, M., Pennisi, G., Bella, R., Rampello, L., Malaguarnera, M., Li, Volti G., and Galvano, F. Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. 2017;96(39):e8117 View abstract. [Efficacy of natural vitamin E on oligospermia and asthenospermia: a prospective multi-centered randomized controlled study of 106 cases]. Vacha, G. M., Giorcelli, G., D'Iddio, S., Valentini, G., Bagiella, E., Procopio, A., di Donato, S., Ashbrook, D., and Corsi, M. L-carnitine addition to dialysis fluid. The role of carnitine supplementation during valproic acid therapy. View abstract. View abstract. Schlenzig JS, Charpentier C, Rabier D, et al. The effect of valproic acid on plasma carnitine levels. Comparison between the effect of L-propionylcarnitine, L- acetylcarnitine and nitroglycerin in chronic peripheral arterial disease: a haemodynamic double blind echo-Doppler study. View abstract. View abstract. Drugs Exp Clin Res 1994;20:169-76. View abstract. Three-year survival of patients with heart failure caused by dilated cardiomyopathy and L-carnitine administration. 2008;47(10):823-825. Clin Rheumatol. View abstract. Carnitine deficiency during valproic acid treatment. Neuro.Endocrinol.Lett. Shakeri, A., Tabibi, H., and Hedayati, M. Effects of L-carnitine supplement on serum inflammatory cytokines, C-reactive protein, lipoprotein (a), and oxidative stress in hemodialysis patients with Lp (a) hyperlipoproteinemia. Sandor, A., Pecsuvac, K., Kerner, J., and Alkonyi, I. Current Therapeutic Research 1981;30(5):753-764. As with any supplement, you should speak with your doctor before taking L-carnitine. Report of one case]. 2008;111(2 Pt 2):522-524. View abstract. Clin Ter. Does carnitine cause insomnia? View abstract. J Infect Dis 1997;176:1517-23. Gut. View abstract. Prolonged oral L-carnitine substitution increases bicycle ergometer performance in patients with severe, ischemically induced cardiac insufficiency. View abstract. Weigel, C., Kiener, C., Meier, N., Schmid, P., Rauh, M., Rascher, W., and Knerr, I. Carnitine status in early-treated children, adolescents and young adults with phenylketonuria on low phenylalanine diets. The dose of your acenocoumarol might need to be changed. Carnitine produces energy in the cells by transporting fatty acids into the mitochondria where they are oxidized into . View abstract. Ellaway, C. J., Peat, J., Williams, K., Leonard, H., and Christodoulou, J. Medium-term open label trial of L-carnitine in Rett syndrome. Ovidius University Annals, Physical Education and Sport/Science, Movement and Health Series 2010;10(Suppl 2):504-507. View abstract. 2010;93(6):1907-1910. View abstract. Warady, B. Ren Fail. View abstract. Our website services, content, and products are for informational purposes only. View abstract. 1 Lancet 12-13-1980;2(8207):1309-1310. Drugs Exp Clin Res 1992;18(4):147-153. Urol.J 2010;7(3):188-193. Neurologia 2007;22(5):329-332. L-Carnitine supplementation in older women. 2014 Jun;63(6):996-1004. However, studies support its use for health, brain function and disease prevention. 2014 Jun;27(3):317-29. 2008;23(7):1602-1606. Nutrition 2009;25(11-12):1193-1201. 2005;25(7):470-477. U.S. Pucciarelli, G., Mastursi, M., Latte, S., Sacra, C., Setaro, A., Lizzadro, A., and Nolfe, G. [The clinical and hemodynamic effects of propionyl-L-carnitine in the treatment of congestive heart failure]. Call your doctor for medical advice about side effects. L-Carnitine L-Tartrate (LCLT) is typically used for physical performance and power output. Cui, G., Xu, W. H., and Wu.G.P. J Anal Toxicol 1996;20:55-8. Jpn Heart J 1984;25(4):587-597. View abstract. View abstract. Di Cesare Mannelli L, Ghelardini C, Calvani M, et al. Int J Clin Pharmacol Res 1995;15:9-15. Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis. View abstract. Avoid taking ALCAR too late in the day, as it can cause insomnia in some people. Hi-Tech Pharmacal Company Inc (2022): 3. Interventions for treating leg ulcers in people with sickle cell disease. Yet, there are a few known side effects that include agitation, insomnia and nausea. 2010;29(4):312-34. A., and Greenhaff, P. L. Increasing muscle carnitine content alters muscle fuel metabolism and improves exercise performance in humans. L-Carnitine in maintenance hemo- dialysis clinical, lipid and biochemical effects. Desbree, A., Houdon, L., Touati, G., Djemili, S., Choker, G., and Flodrops, H. [EBV infection revealing a long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency in a 3-year-old boy]. View abstract. View abstract. 2008;29(2):261-266. J Neurol.Sci 3-15-2004;218(1-2):103-108. 2009;(2):CD006659. Disclaimer: Go To See My Account. 2006;39(4):465-474. Biagiotti G, Cavallini G. Acetyl-L-carnitine vs tamoxifen in the oral therapy of Peyronie's disease: a preliminary report. Do not mix citicoline with levodopa, a medication used to treat Parkinson's disease, without talking to your doctor. 2010;37(12):2353-2354. They may have you stop lipotropics or switch the ingredients being used. Elmslie, J. L., Porter, R. J., Joyce, P. R., Hunt, P. J., and Mann, J. I. Carnitine does not improve weight loss outcomes in valproate-treated bipolar patients consuming an energy-restricted, low-fat diet. Control of valproate-induced hepatotoxicity with carnitine. Last updated on Aug 31, 2022. 2007;12 Suppl 1:43-51. Signorelli, S. S., Fatuzzo, P., Rapisarda, F., Neri, S., Ferrante, M., Oliveri, Conti G., Fallico, R., Di, Pino L., Pennisi, G., Celotta, G., and Massimiliano, A.