microcrystalline cellulose msds fmc microcrystalline cellulose msds fmc

%PDF-1.3 MSDS Ref. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . . : 9004-34-6 Date Approved: 01/31/2008 . The aqueous solution to barrier membrane coating. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. Explore how we work and why we apply science and creativity for a better world to everything we do. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Explore how you can develop your career and bring your creative ideas to life at IFF. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. stream Find answers in our support articles. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. Avicel Microcrystalline Cellulose: Chemical Identifiers. <> EMCOCEL 90 M. 130. /Parent 3 0 R Molecular weight: Not Applicable 1.5. No. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. It . 4 0 obj . These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. w !1AQaq"2B #3Rbr Report Category. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. ). /Contents 4 0 R endobj Microcrystalline Cellulose (MCC) Manufacturing Industry. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P The typical mean particle size is 20200 m. However, it yields non-digestible fibre. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. endobj It is available in different grades and particle sizes. MSDS Ref. JFIF ` ` ZExif MM * J Q Q Q C The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. stream /Type/Page Battista, O. Medium size standard MCC grade, suited for the majority of directly compressible actives. Product Name Cellulose microcrystalline. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. Alginates also function as actives in some anti-reflux products. xv}O2' H~KEe9>G/,:9\i It is a white, free-flowing powder. EINECS #: 232-674-9 1.7. Have an order or account question, find answers in our Online Support articles. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . These grades have particle sizes ranging from <30 to approximately 200. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. 102331. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Well-recognized product that can do it all. Chemical Formula: (C6H10O5)n 1.4. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. endobj endobj 1 0 obj Hi, let us know if you have any questions as you visit our website. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> BIOACCUMULATIVE POTENTIAL Synergies to simplify formulation challenges and reduce operational costs. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. SCMm_>x^O9l (n. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. In 1964 FMC, Corporation . Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. <> Watch Now. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine Have an order or account question? Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. Revision No. CAS 9004-34-6, pH 5 - 7.5. : 5. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. SDS - Safety Data Sheet. << IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. stream <> In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) Microcrystalline cellulose (C6H10O5)n is refined wood pulp. The most. PDF (28.38 mb) 2022 Corporate Fact Sheet. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . 0.25 - 0.37. 4 0 obj The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. No. %PDF-1.5 %PDF-1.4 CAS #: 9004-34-6 . Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. CAS #: 9004-34-6 iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL Safety Data Sheet (SDS) Viewer. stream q9;v80q>jZ Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. 1 0 obj MCC helps in the formation of spheres because of its . A., and Smith, P. A. It is also inert and biocompatible. % More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. 4 0 obj Revision No. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? Cellulose microcrystalline. Superior Performance: Provides excellent water uptake and rapid swelling . FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . 2 0 obj Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. No. gwf;J(e0o|1p{R~P^);ao!%{0KD7. CoA. The cellulose molecule is formed through repeated condensation of cellobiose units. CAS No. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Synonyms: Cellulose, Cellulose powder, Cotton linters. Molecular Weight null. endobj All Rights Reserved. >> Microcrystalline Cellulose E460 MSDS 1. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. Product Name: Microcrystalline Cellulose E460 1.2. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Validity Area. Heavy metals, % NMT 0.001 The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. We know that our customers need to provide reliable and consistent products to their patients. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. If you are already a ChemPoint customer then sign up for access to our online ordering website. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. Date Approved: 05/25/2010. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. Watch Now. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? 1 0 obj Microcrystalline Cellulose (MCC) MSDS 1. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. The data shown below apply only to Avicel PH 101. MATERIAL SAFETY DATA SHEET. 6 Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. POLYOX resins are nonionic polyethylene oxide solubility polymers. pH 6.0 to 8.0 . The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. Chemical Formula: (C6H10O5)n 1.4. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. Molecular weight: Not Applicable 1.5. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. 1.3. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? Origin(s): Plant/Botanical. Safety Data Sheet for Cellulose microcrystalline 102331. LOT #: Available upon request. Eur., JPE . The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. These, in turn, are assembled into fibrils in the cell wall. Avicel RC-591 & CL-611 - Description. common form is used in vitamin supplements or tablets. We are artists at heart and creators by nature. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). ( ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" : 160182 Date Approved: 05/25/2010 Revision No. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. Material safety data sheet - FMC Corporation. gac74 [#B6`Wnw7 /Resources 2 0 R GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. 3 0 obj There have always been two different points of view for the liquidity of MCC. CAS 9004-34-6. ( Combines good flow and high compactibility. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. Are you looking for information about products and services by region? The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. Are you sure you want to delete your template? To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. Page 1 of 8. PDF (2.77 mb) 2021 FMC Sustainability Report. 130. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. High performance lubricant that brings more to the tablet. Instead, they obtained a stable colloidal suspension. Avicel PC 611 (FMC Biopolymer) . A family of polysaccharide products that allow distinctive drug delivery solutions. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. . Home. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . endobj Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. 9,LL!z From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. CAS #: 9004-34-6 1.6. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements.